Mechanisms of inflammasome activation: recent advances and novel insights

Mechanisms of inflammasome activation: recent advances and novel insights

Highlights • New inflammasomes and new microbial triggers of inflammasomes have been identified. • Cytosolic LPS is detected by caspase-11 resulting in its activation. • A novel pyrin inflammasome responds to pathogen-induced modifications of host proteins. • Identification of a new NLRP6 pathway co...

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Veröffentlicht in:Trends in cell biology 2015-05, Vol.25 (5), p.308-315
Hauptverfasser: Vanaja, Sivapriya K, Rathinam, Vijay A.K, Fitzgerald, Katherine A
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Caspase 1 - metabolism
Cell Death
Cytosol - metabolism
Humans
Inflammasomes - metabolism
Interleukin-18 - metabolism
Interleukin-1beta - metabolism
Mice
Pathology
Signal Transduction
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Beschreibung
Zusammenfassung:Highlights • New inflammasomes and new microbial triggers of inflammasomes have been identified. • Cytosolic LPS is detected by caspase-11 resulting in its activation. • A novel pyrin inflammasome responds to pathogen-induced modifications of host proteins. • Identification of a new NLRP6 pathway controlling mucus production.
ISSN:0962-8924
1879-3088
DOI:10.1016/j.tcb.2014.12.009