FBXO11 promotes ubiquitination of the Snail family of transcription factors in cancer progression and epidermal development

Highlights • FBXO11 interacts with and degrades the EMT-driving Snail transcription factors. • FBXO11 inhibits EMT and tumor invasion and is a favorable prognostic factor. • FBXO11 deficient mice show increased Snail protein levels and epidermal hyperplasia. • Epistasis analysis in C. elegans valida...

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Veröffentlicht in:	Cancer letters 2015-06, Vol.362 (1), p.70-82
Hauptverfasser:	Jin, Yue, Shenoy, Anitha K, Doernberg, Samuel, Chen, Hao, Luo, Huacheng, Shen, Huangxuan, Lin, Tong, Tarrash, Miriam, Cai, Qingsong, Hu, Xin, Fiske, Ryan, Chen, Ting, Wu, Lizi, Mohammed, Kamal A, Rottiers, Veerle, Lee, Siu Sylvia, Lu, Jianrong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Breast Neoplasms - metabolism Breast Neoplasms - pathology Caenorhabditis elegans Cancer Cell adhesion & migration Cell cycle Cell growth Disease Progression E-cadherin EMT Epidermis Epidermis - growth & development Epidermis - metabolism Epithelial-Mesenchymal Transition F-box F-Box Proteins - genetics F-Box Proteins - metabolism Female Gene expression Genotype & phenotype Hematology, Oncology and Palliative Medicine Humans Male MCF-7 Cells Metastasis Mice Mice, Inbred C57BL Morphogenesis Physiology Protein-Arginine N-Methyltransferases - genetics Protein-Arginine N-Methyltransferases - metabolism Proteins Rodents Scratch Snai1 Snail Family Transcription Factors Spermatogenesis Transcription factors Transcription Factors - metabolism Ubiquitination
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Beschreibung
Zusammenfassung:	Highlights • FBXO11 interacts with and degrades the EMT-driving Snail transcription factors. • FBXO11 inhibits EMT and tumor invasion and is a favorable prognostic factor. • FBXO11 deficient mice show increased Snail protein levels and epidermal hyperplasia. • Epistasis analysis in C. elegans validates the FBXO11-Snail regulatory axis.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2015.03.037