RNA-binding proteins in neurodegeneration: Seq and you shall receive

RNA-binding proteins in neurodegeneration: Seq and you shall receive

Highlights • RNA-binding proteins (RBPs) are implicated in several neurodegenerative diseases. • A thorough understanding of the role of RBPs in neurodegeneration is lacking. • High-throughput techniques reveal novel mechanisms of RBP-mediated neuropathology. • Applying high-throughput techniques wi...

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Veröffentlicht in:Trends in neurosciences (Regular ed.) 2015-04, Vol.38 (4), p.226-236
Hauptverfasser: Nussbacher, Julia K, Batra, Ranjan, Lagier-Tourenne, Clotilde, Yeo, Gene W
Format: Artikel
Sprache:eng
Schlagworte:
Animals
High-Throughput Nucleotide Sequencing
high-throughput sequencing
Homeostasis
Humans
neurodegeneration
Neurodegenerative Diseases - genetics
Neurodegenerative Diseases - metabolism
Neurological disorders
Neurology
Pathogenesis
polyadenylation
Proteins
Ribonucleic acid
RNA
RNA binding protein
RNA Processing, Post-Transcriptional
RNA-Binding Proteins - genetics
RNA-Binding Proteins - metabolism
splicing
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Beschreibung
Zusammenfassung:Highlights • RNA-binding proteins (RBPs) are implicated in several neurodegenerative diseases. • A thorough understanding of the role of RBPs in neurodegeneration is lacking. • High-throughput techniques reveal novel mechanisms of RBP-mediated neuropathology. • Applying high-throughput techniques will provide novel therapeutic targets. • Tissue heterogeneity remains an obstacle to understanding neuronal diseases.
ISSN:0166-2236
1878-108X
DOI:10.1016/j.tins.2015.02.003