A re-evaluation of the role of B cells in protective immunity to Chlamydia infection

Highlights • Chlamydia is the most commonly reported bacterial STI worldwide. • T cells, but not B cells, are thought to be important for Chlamydia clearance. • We summarize recent progress on understanding the role of B cells in Chlamydia infection. • We discuss how B cells can contribute to host d...

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Veröffentlicht in:	Immunology letters 2015-04, Vol.164 (2), p.88-93
Hauptverfasser:	Li, Lin-Xi, McSorley, Stephen J
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Antibodies, Bacterial - immunology Antibody B cells B-Lymphocytes - immunology B-Lymphocytes - metabolism B-Lymphocytes - microbiology Biological Evolution Chlamydia Chlamydia Infections - genetics Chlamydia Infections - immunology Chlamydia Infections - metabolism Chlamydia Infections - prevention & control Chlamydia trachomatis - immunology Disease Models, Animal Host-Pathogen Interactions - immunology Humans Immunity Intracellular infections Mice
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Beschreibung
Zusammenfassung:	Highlights • Chlamydia is the most commonly reported bacterial STI worldwide. • T cells, but not B cells, are thought to be important for Chlamydia clearance. • We summarize recent progress on understanding the role of B cells in Chlamydia infection. • We discuss how B cells can contribute to host defense against intracellular pathogens.
ISSN:	0165-2478 1879-0542
DOI:	10.1016/j.imlet.2015.02.004