Comparison of Saliva Pcr Assay Versus Rapid Culture for Detection of Congenital Cytomegalovirus Infection

Comparison of Saliva Pcr Assay Versus Rapid Culture for Detection of Congenital Cytomegalovirus Infection

As part of the CMV and Hearing Multicenter Screening (CHIMES) study, 72,239 newborns were screened for cytomegalovirus by rapid culture and real-time PCR of saliva samples. Of the 266 infants with congenital cytomegalovirus infection, discordance between rapid culture and PCR was observed in 14 chil...

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Veröffentlicht in:The Pediatric infectious disease journal 2015-05, Vol.34 (5), p.536-537
Hauptverfasser: Pinninti, Swetha G, Ross, Shannon A, Shimamura, Masako, Novak, Zdenek, Palmer, April L, Ahmed, Amina, Tolan, Robert W, Bernstein, David I, Michaels, Marian G, Sánchez, Pablo J, Fowler, Karen B, Boppana, Suresh B
Format: Artikel
Sprache:eng
Schlagworte:
Cytomegalovirus Infections - congenital
Cytomegalovirus Infections - diagnosis
Cytomegalovirus Infections - virology
Humans
Infant, Newborn
Prospective Studies
Real-Time Polymerase Chain Reaction - methods
Saliva - virology
United States
Viral Load
Virology - methods
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Zusammenfassung:As part of the CMV and Hearing Multicenter Screening (CHIMES) study, 72,239 newborns were screened for cytomegalovirus by rapid culture and real-time PCR of saliva samples. Of the 266 infants with congenital cytomegalovirus infection, discordance between rapid culture and PCR was observed in 14 children, and 13 were identified only by PCR, demonstrating the superiority of the PCR assay.
ISSN:0891-3668
1532-0987
DOI:10.1097/INF.0000000000000609