Protein networks and activation of lymphocytes

Protein networks and activation of lymphocytes

Highlights • Mass spectrometry (MS) enables the unbiased and comprehensive study of lymphocyte signaling. • New ‘omics’ fields in immunology are emerging from MS. • Biological replicates are crucial to ascertain statistical significance in MS-based studies.

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Bibliographische Detailangaben
Veröffentlicht in:Current opinion in immunology 2015-04, Vol.33, p.78-85
Hauptverfasser: Helou, Ynes A, Salomon, Arthur R
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
Animals
Computational Biology - methods
Datasets as Topic
Humans
Lymphocyte Activation
Lymphocytes - immunology
Lymphocytes - metabolism
Models, Statistical
Phosphorylation
Phosphotransferases - metabolism
Protein Binding
Protein Interaction Mapping
Protein Interaction Maps
Proteome
Proteomics - methods
Signal Transduction
Single-Cell Analysis
Substrate Specificity
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Beschreibung
Zusammenfassung:Highlights • Mass spectrometry (MS) enables the unbiased and comprehensive study of lymphocyte signaling. • New ‘omics’ fields in immunology are emerging from MS. • Biological replicates are crucial to ascertain statistical significance in MS-based studies.
ISSN:0952-7915
1879-0372
DOI:10.1016/j.coi.2015.01.019