Glutamate neurons within the midbrain dopamine regions

Highlights • VGluT2-expressing glutamate neurons reside within RRF, SNC, and VTA. • Some VTA VGluT2 neurons, but not RRF or SNC VGluT2 neurons, co-express tyrosine hydroxylase. • Subsets of VGluT2-TH neurons co-express or lack VMAT2, DAT, or D2 receptor. • VTA VGluT2 neurons exhibit local VTA projec...

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Veröffentlicht in:	Neuroscience 2014-12, Vol.282, p.60-68
Hauptverfasser:	Morales, M, Root, D.H
Format:	Artikel
Sprache:	eng
Schlagworte:	Addiction Animals Behavior, Addictive - metabolism dopamine Dopamine - metabolism Glutamic Acid - metabolism Neurology Neurons - metabolism retrorubral field substantia nigra Tegmentum Mesencephali - metabolism ventral tegmental area Vesicular Glutamate Transport Protein 2 - metabolism VGluT2
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Zusammenfassung:	Highlights • VGluT2-expressing glutamate neurons reside within RRF, SNC, and VTA. • Some VTA VGluT2 neurons, but not RRF or SNC VGluT2 neurons, co-express tyrosine hydroxylase. • Subsets of VGluT2-TH neurons co-express or lack VMAT2, DAT, or D2 receptor. • VTA VGluT2 neurons exhibit local VTA projections as well as and extrinsic projections. • Accumbens medial shell is a preferential target of VTA VGluT2-TH neurons.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2014.05.032