GABAergic interneuron transplants to study development and treat disease

Highlights • Cortical GABAergic interneurons migrate tangentially from the subcortical forebrain into the cerebral cortex. • Transplants of cortical interneuron precursors migrate extensively after engraftment into a variety of CNS tissues. • This ability to integrate post-transplant is being applie...

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Veröffentlicht in:	Trends in neurosciences (Regular ed.) 2014-03, Vol.37 (3), p.169-177
Hauptverfasser:	Tyson, Jennifer A, Anderson, Stewart A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain Brain Tissue Transplantation Cell adhesion & migration Cell Differentiation - physiology GABAergic Neurons - transplantation Humans Interneurons - transplantation Neural Stem Cells - transplantation Neurogenesis - physiology Neurological disorders Neurology Neurons Stem Cell Transplantation Stem cells
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Beschreibung
Zusammenfassung:	Highlights • Cortical GABAergic interneurons migrate tangentially from the subcortical forebrain into the cerebral cortex. • Transplants of cortical interneuron precursors migrate extensively after engraftment into a variety of CNS tissues. • This ability to integrate post-transplant is being applied to the study of aspects of development and excitingly to the development of cell-based therapies for a variety of CNS disorders.
ISSN:	0166-2236 1878-108X
DOI:	10.1016/j.tins.2014.01.003