Structural Basis of Latrophilin-FLRT Interaction

Latrophilins, receptors for spider venom α-latrotoxin, are adhesion type G-protein-coupled receptors with emerging functions in synapse development. The N-terminal region binds the endogenous cell adhesion molecule FLRT, a major regulator of cortical and synapse development. We present crystallograp...

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Veröffentlicht in:	Structure (London) 2015-04, Vol.23 (4), p.774-781
Hauptverfasser:	Jackson, Verity A., del Toro, Daniel, Carrasquero, Maria, Roversi, Pietro, Harlos, Karl, Klein, Rüdiger, Seiradake, Elena
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Binding Sites HEK293 Cells HeLa Cells Humans Membrane Glycoproteins - chemistry Membrane Glycoproteins - metabolism Mice Molecular Sequence Data Protein Binding Receptors, G-Protein-Coupled - chemistry Receptors, G-Protein-Coupled - metabolism Receptors, Peptide - chemistry Receptors, Peptide - metabolism Short
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