Light sensitization of DNA nanostructures via incorporation of photo-cleavable spacers

Light sensitization of DNA nanostructures via incorporation of photo-cleavable spacers

Using light irradiation as a trigger, large-scale structural reconfiguration of DNA nanostructures is demonstrated. We incorporated photo-cleavable spacers at strategic locations within the short oligonucleotide strands connecting adjacent helices within a DNA origami sphere, and then used light to...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2015-04, Vol.51 (26), p.5747-5750
Hauptverfasser: Kohman, Richie E, Han, Xue
Format: Artikel
Sprache:eng
Schlagworte:
DNA - chemistry
DNA - radiation effects
Light
Nanostructures - chemistry
Nanostructures - radiation effects
Photolysis
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Zusammenfassung:Using light irradiation as a trigger, large-scale structural reconfiguration of DNA nanostructures is demonstrated. We incorporated photo-cleavable spacers at strategic locations within the short oligonucleotide strands connecting adjacent helices within a DNA origami sphere, and then used light to transform the sphere into two tethered hemispheres.
ISSN:1359-7345
1364-548X
DOI:10.1039/c5cc00082c