Optimum chemotherapy for the management of advanced biliary tract cancer

Biliary tract cancers(BTCs) are highly fatal malignancies, which are often diagnosed at an advanced stage and have relatively poor prognosis.The treatment of patients with advanced BTC is systemic, based on chemotherapy or best supportive care, depending on their performance status.Despite clinical...

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Veröffentlicht in:	World journal of gastroenterology : WJG 2015-04, Vol.21 (14), p.4121-4125
Hauptverfasser:	Ghosn, Marwan, Kourie, Hampig Raphael, El Rassy, Elie, Chebib, Ralph, El Karak, Fadi, Hanna, Colette, Nasr, Dolly
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biliary Biliary Tract Neoplasms - drug therapy Biliary Tract Neoplasms - mortality Biliary Tract Neoplasms - pathology cancer Chemotherapy Updates Treatmen Humans Minireviews Molecular Targeted Therapy Signal Transduction - drug effects tract Treatment Outcome
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Beschreibung
Zusammenfassung:	Biliary tract cancers(BTCs) are highly fatal malignancies, which are often diagnosed at an advanced stage and have relatively poor prognosis.The treatment of patients with advanced BTC is systemic, based on chemotherapy or best supportive care, depending on their performance status.Despite clinical trials studyingmany chemotherapeutic regimens and targeted therapies for the treatment of BTC, the standard of care for advanced BTC remains the combination of gemcitabine with cisplatin.Many new molecules targeting proliferation and survival pathways, the immune response and angiogenesis are currently undergoing phase Ⅰ and Ⅱ trials for the treatment of advanced BTC with promising results.
ISSN:	1007-9327 2219-2840
DOI:	10.3748/wjg.v21.i14.4121