RC-3095, a Selective Gastrin-Releasing Peptide Receptor Antagonist, Does Not Protect the Lungs in an Experimental Model of Lung Ischemia-Reperfusion Injury

RC-3095, a selective GRPR antagonist, has been shown to have anti-inflammatory properties in different models of inflammation. However, its protective effect on lungs submitted to lung ischemia-reperfusion injury has not been addressed before. Then, we administrated RC-3095 intravenously before and...

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Veröffentlicht in:	BioMed research international 2015-01, Vol.2015 (2015), p.1-7
Hauptverfasser:	Andrade, Cristiano Feijó, Ulbrich, Jane Maria, De Angelis, Kátia, Malfitano, Christiane, Simoneti, Lucas Elias Lise, Thomaz, Leonardo Dalla Giacomassa Rocha, Oliveira-Freitas, Vera L., Schwartsmann, Gilberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Apoptosis Biomedical research Bombesin - analogs & derivatives Bombesin - pharmacology Cytokines Disease Models, Animal Drug dosages Gases Gastrin Interleukin-1beta - metabolism Ischemia Laboratory animals Lung - metabolism Lung - pathology Lung Diseases - drug therapy Lung Diseases - metabolism Lung Diseases - pathology Lungs Male Nitric Oxide Synthase Type III - metabolism Ostomy Peptide Fragments - pharmacology Peptides Physiological aspects Rats Rats, Wistar Receptors, Bombesin - antagonists & inhibitors Receptors, Bombesin - metabolism Reperfusion injury Reperfusion Injury - drug therapy Reperfusion Injury - metabolism Reperfusion Injury - pathology Rodents Studies Thoracic surgery Tumor Necrosis Factor-alpha - metabolism Ventilation
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Zusammenfassung:	RC-3095, a selective GRPR antagonist, has been shown to have anti-inflammatory properties in different models of inflammation. However, its protective effect on lungs submitted to lung ischemia-reperfusion injury has not been addressed before. Then, we administrated RC-3095 intravenously before and after lung reperfusion using an animal model of lung ischemia-reperfusion injury (LIRI) by clamping the pulmonary hilum. Twenty Wistar rats were subjected to an experimental model in four groups: SHAM, ischemia-reperfusion (IR), RC-Pre, and RC-Post. The final mean arterial pressure significantly decreased in IR and RC-Pre compared to their values before reperfusion (P
ISSN:	2314-6133 2314-6141
DOI:	10.1155/2015/496378