The STING pathway and the T cell-inflamed tumor microenvironment

Highlights • A T cell-inflamed tumor microenvironment is associated with benefit to immunotherapies. • The mechanism of endogenous T cell priming against tumor antigens has been elusive. • Mechanistic data indicate a crucial role for type I IFNs as a bridge to adaptive immunity. • Recent data implic...

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Veröffentlicht in:	Trends in immunology 2015-04, Vol.36 (4), p.250-256
Hauptverfasser:	Woo, Seng-Ryong, Corrales, Leticia, Gajewski, Thomas F
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Antigens Cancer Deoxyribonucleic acid DNA Gene expression Humans Immune system Immunotherapy Interferons - genetics Interferons - immunology Kinases Lymphocytes Melanoma Metastasis Neoplasms - immunology Neoplasms - pathology Patients T-Lymphocytes - immunology Tumor Microenvironment Tumors
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Beschreibung
Zusammenfassung:	Highlights • A T cell-inflamed tumor microenvironment is associated with benefit to immunotherapies. • The mechanism of endogenous T cell priming against tumor antigens has been elusive. • Mechanistic data indicate a crucial role for type I IFNs as a bridge to adaptive immunity. • Recent data implicate the host STING pathway in innate immune sensing of tumors.
ISSN:	1471-4906 1471-4981
DOI:	10.1016/j.it.2015.02.003