Characterizing immune repertoires by high throughput sequencing: strategies and applications

Characterizing immune repertoires by high throughput sequencing: strategies and applications

Highlights • Diverse lymphocyte repertoires can be analyzed by high throughput sequencing. • Immunoglobulin and T cell receptor genes are technically challenging sequencing targets. • Various methods and analyses can be used for antigen receptor repertoire sequencing. • High throughput repertoire se...

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Veröffentlicht in:Trends in immunology 2014-12, Vol.35 (12), p.581-590
Hauptverfasser: Calis, Jorg J.A, Rosenberg, Brad R
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
antibody diversity
Antigens
high throughput sequencing
immune profiling
immune repertoires
Immune system
immunoglobulin diversity
Lymphocytes
T cell receptor diversity
T cell receptors
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container_title Trends in immunology
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creator Calis, Jorg J.A
Rosenberg, Brad R
description Highlights • Diverse lymphocyte repertoires can be analyzed by high throughput sequencing. • Immunoglobulin and T cell receptor genes are technically challenging sequencing targets. • Various methods and analyses can be used for antigen receptor repertoire sequencing. • High throughput repertoire sequencing has applications in basic and clinical immunology.
doi_str_mv 10.1016/j.it.2014.09.004
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source Elsevier ScienceDirect Journals
subjects Allergy and Immunology
antibody diversity
Antigens
high throughput sequencing
immune profiling
immune repertoires
Immune system
immunoglobulin diversity
Lymphocytes
T cell receptor diversity
T cell receptors
title Characterizing immune repertoires by high throughput sequencing: strategies and applications
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