Characterizing immune repertoires by high throughput sequencing: strategies and applications

Highlights • Diverse lymphocyte repertoires can be analyzed by high throughput sequencing. • Immunoglobulin and T cell receptor genes are technically challenging sequencing targets. • Various methods and analyses can be used for antigen receptor repertoire sequencing. • High throughput repertoire se...

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Veröffentlicht in:	Trends in immunology 2014-12, Vol.35 (12), p.581-590
Hauptverfasser:	Calis, Jorg J.A, Rosenberg, Brad R
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology antibody diversity Antigens high throughput sequencing immune profiling immune repertoires Immune system immunoglobulin diversity Lymphocytes T cell receptor diversity T cell receptors
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Beschreibung
Zusammenfassung:	Highlights • Diverse lymphocyte repertoires can be analyzed by high throughput sequencing. • Immunoglobulin and T cell receptor genes are technically challenging sequencing targets. • Various methods and analyses can be used for antigen receptor repertoire sequencing. • High throughput repertoire sequencing has applications in basic and clinical immunology.
ISSN:	1471-4906 1471-4981
DOI:	10.1016/j.it.2014.09.004