Ganciclovir penetrates into the cerebrospinal fluid of an infant with congenital cytomegalovirus infection

Currently, there is no evidence whether ganciclovir, or its oral prodrug valganciclovir, penetrates into the cerebrospinal fluid of human infants treated for congenital cytomegalovirus infection. Here, we report a case study providing evidence that ganciclovir, administered as valganciclovir, reache...

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Veröffentlicht in:	Italian journal of pediatrics 2015-03, Vol.41 (1), p.26-26, Article 26
Hauptverfasser:	Natale, Fabio, Bizzarri, Bianca, Cardi, Veronica, Gaeta, Aurelia, Villani, Paola, Liuzzi, Giuseppina, De Curtis, Mario
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antiviral Agents - administration & dosage Antiviral Agents - pharmacology Antiviral Agents - therapeutic use Case Report Cytomegalovirus Infections - cerebrospinal fluid Cytomegalovirus Infections - congenital DNA, Viral - analysis Female Ganciclovir - administration & dosage Ganciclovir - analogs & derivatives Ganciclovir - pharmacology Ganciclovir - therapeutic use Humans Infant, Newborn Pregnancy Pregnancy Complications, Infectious
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Beschreibung
Zusammenfassung:	Currently, there is no evidence whether ganciclovir, or its oral prodrug valganciclovir, penetrates into the cerebrospinal fluid of human infants treated for congenital cytomegalovirus infection. Here, we report a case study providing evidence that ganciclovir, administered as valganciclovir, reaches the infant's cerebrospinal fluid when used at the currently recommended dose for congenital cytomegalovirus infection.
ISSN:	1824-7288 1824-7288
DOI:	10.1186/s13052-015-0132-8