Assessment of PaO2/FiO2 for stratification of patients with moderate and severe acute respiratory distress syndrome

Objectives A recent update of the definition of acute respiratory distress syndrome (ARDS) proposed an empirical classification based on ratio of arterial partial pressure of oxygen to fraction of inspired oxygen (PaO2/FiO2) at ARDS onset. Since the proposal did not mandate PaO2/FiO2 calculation und...

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Veröffentlicht in:	BMJ open 2015-03, Vol.5 (3), p.e006812-e006812
Hauptverfasser:	Villar, Jesús, Blanco, Jesús, del Campo, Rafael, Andaluz-Ojeda, David, Díaz-Domínguez, Francisco J, Muriel, Arturo, Córcoles, Virgilio, Suárez-Sipmann, Fernando, Tarancón, Concepción, González-Higueras, Elena, López, Julia, Blanch, Lluis, Pérez-Méndez, Lina, Fernández, Rosa Lidia, Kacmarek, Robert M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Area Under Curve Blood Gas Analysis Epidemiology Female Hospital Mortality Hospitals, Teaching Humans Inhalation Intensive Care Lung - physiopathology Male Middle Aged Monitoring, Physiologic - methods Mortality Oxygen - physiology Partial Pressure Patients Pneumonia Positive-Pressure Respiration Prospective Studies Respiration, Artificial - methods Respiratory distress syndrome Respiratory Distress Syndrome, Adult - diagnosis Respiratory Distress Syndrome, Adult - mortality Respiratory Distress Syndrome, Adult - physiopathology ROC Curve Sepsis Severe Acute Respiratory Syndrome - diagnosis Severe Acute Respiratory Syndrome - mortality Severe Acute Respiratory Syndrome - physiopathology Severity of Illness Index Tidal Volume Trauma Variables Ventilators
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Zusammenfassung:	Objectives A recent update of the definition of acute respiratory distress syndrome (ARDS) proposed an empirical classification based on ratio of arterial partial pressure of oxygen to fraction of inspired oxygen (PaO2/FiO2) at ARDS onset. Since the proposal did not mandate PaO2/FiO2 calculation under standardised ventilator settings (SVS), we hypothesised that a stratification based on baseline PaO2/FiO2 would not provide accurate assessment of lung injury severity. Design A prospective, multicentre, observational study. Setting A network of teaching hospitals. Participants 478 patients with eligible criteria for moderate (100
ISSN:	2044-6055 2044-6055
DOI:	10.1136/bmjopen-2014-006812