Circulating Soluble Neuropilin-1 in Patients with Early Cervical Cancer and Cervical Intraepithelial Neoplasia Can Be Used as a Valuable Diagnostic Biomarker

Objective. To investigate soluble neuropilin-1 (sNRP-1) in circulating and NRP-1 protein in cervical tissues from patients with cervical cancer or cervical intraepithelial neoplasia (CIN). Methods. sNRP-1 was measured in 64 preoperative patients and 20 controls. NRP-1 protein in cervical tissue was...

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Veröffentlicht in:	Disease markers 2015-01, Vol.2015 (2015), p.1-8
Hauptverfasser:	Wang, Zehua, Wan, Yinglu, Wang, Xiaoling, Huang, Zaiju, Cheng, Henghui, Yang, Shouhua, Cai, Jing
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biological markers Biomarkers, Tumor - blood Care and treatment Case-Control Studies Cervical cancer Cervical Intraepithelial Neoplasia - blood Cervical Intraepithelial Neoplasia - pathology Diagnosis Female Genetic aspects Humans Identification and classification Membrane proteins Middle Aged Neuropilin-1 - blood Prognosis Properties Uterine Cervical Neoplasms - blood Uterine Cervical Neoplasms - pathology
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Zusammenfassung:	Objective. To investigate soluble neuropilin-1 (sNRP-1) in circulating and NRP-1 protein in cervical tissues from patients with cervical cancer or cervical intraepithelial neoplasia (CIN). Methods. sNRP-1 was measured in 64 preoperative patients and 20 controls. NRP-1 protein in cervical tissue was detected in 56 patients and 20 controls. Results. Both sNRP-1 and NRP-1 proteins were correlated with stage. sNRP-1 presented a high diagnostic ability of cervical cancer and CIN, with a sensitivity of 70.97% and a specificity of 73.68%. Conclusions. sNRP-1 in circulating can serve as a possible valuable diagnostic biomarker for cervical cancer and CIN.
ISSN:	0278-0240 1875-8630
DOI:	10.1155/2015/506428