Integrins and cancer: regulators of cancer stemness, metastasis, and drug resistance

Highlights • Integrins contribute to cancer progression via adhesion-dependent and -independent pathways. • Specific integrins not only represent stem cell markers, but also dictate stem cell behavior. • Integrins drive therapeutic resistance through canonical and non-canonical mechanisms. • Integri...

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Veröffentlicht in:	Trends in cell biology 2015-04, Vol.25 (4), p.234-240
Hauptverfasser:	Seguin, Laetitia, Desgrosellier, Jay S, Weis, Sara M, Cheresh, David A
Format:	Artikel
Sprache:	eng
Schlagworte:	cancer Cell Adhesion drug resistance Drug Resistance - drug effects Humans integrins Integrins - metabolism Neoplasm Metastasis - therapy Neoplasms - metabolism Neoplasms - therapy Pathology Signal Transduction Stem Cells - metabolism stemness Stromal Cells
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Beschreibung
Zusammenfassung:	Highlights • Integrins contribute to cancer progression via adhesion-dependent and -independent pathways. • Specific integrins not only represent stem cell markers, but also dictate stem cell behavior. • Integrins drive therapeutic resistance through canonical and non-canonical mechanisms. • Integrin expression contributes to multiple steps of the metastatic cascade.
ISSN:	0962-8924 1879-3088
DOI:	10.1016/j.tcb.2014.12.006