Estrogen receptor agonists for attenuation of neuroinflammation and neurodegeneration

Highlights • Estrogen receptor (ER) agonists play crucial roles in the immune system and the CNS. • Cell signaling pathways are modulated by ER agonists via binding to ERα and ERβ. • ER agonists can promote transcription of a large number of neuroprotective genes. • Neuroinflammation and neurodegene...

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Veröffentlicht in:	Brain research bulletin 2014-10, Vol.109, p.22-31
Hauptverfasser:	Chakrabarti, Mrinmay, Haque, Azizul, Banik, Naren L, Nagarkatti, Prakash, Nagarkatti, Mitzi, Ray, Swapan K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Encephalitis - drug therapy Estrogen receptor agonists Estrogens - pharmacology Estrogens - therapeutic use Humans Inflammation Neurodegenerative Diseases - drug therapy Neurodisorders Neurology Neuroprotection Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Signal Transduction - drug effects
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Beschreibung
Zusammenfassung:	Highlights • Estrogen receptor (ER) agonists play crucial roles in the immune system and the CNS. • Cell signaling pathways are modulated by ER agonists via binding to ERα and ERβ. • ER agonists can promote transcription of a large number of neuroprotective genes. • Neuroinflammation and neurodegeneration in the CNS are prevented by ER agonists. • ER agonists play significant roles in enhancing memory and cognition.
ISSN:	0361-9230 1873-2747
DOI:	10.1016/j.brainresbull.2014.09.004