Helicobacter hepaticus infection in BALB/c mice abolishes subunit-vaccine-induced protection against M. tuberculosis

Highlights • Neonatal Hh infection of mice upregulates colonic IL10 message. • Neonatal Hh infection reduces lung immune responses after immunisation with Ad85A. • Protection against Mtb challenge induced by Ad85A is abolished in Hh infected mice. • IL10R blockade reverses the effects of Hh infectio...

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Veröffentlicht in:	Vaccine 2015-04, Vol.33 (15), p.1808-1814
Hauptverfasser:	Arnold, Isabelle C, Hutchings, Claire, Kondova, Ivanela, Hey, Ariann, Powrie, Fiona, Beverley, Peter, Tchilian, Elma
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviruses, Human - genetics Administration, Intranasal Allergy and Immunology Animals antibodies Antigens Antigens, Bacterial - immunology bacteria Bacterial Load colon Colon - immunology environmental exposure Experiments Gastrointestinal Microbiome Helicobacter hepaticus Helicobacter hepaticus - growth & development Helicobacter hepaticus - physiology Helicobacter Infections - immunology Helicobacter Infections - microbiology Human adenovirus Human mastadenovirus C Humans Immune response Immunization Infections Interleukin 10 Interleukin-10 - genetics Interleukin-10 - immunology intestinal microorganisms Laboratories Lung - immunology Lung - pathology Lung - ultrastructure Lungs Lymphatic system Lymphocytes messenger RNA Mice Mice, Inbred BALB C Microbiota Mortality Mycobacterium tuberculosis Mycobacterium tuberculosis - pathogenicity Organisms protective effect Subunit vaccine subunit vaccines Tuberculosis Tuberculosis - prevention & control Tuberculosis Vaccines - immunology Vaccines Vaccines, Subunit - immunology Vaccines, Synthetic - immunology
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Zusammenfassung:	Highlights • Neonatal Hh infection of mice upregulates colonic IL10 message. • Neonatal Hh infection reduces lung immune responses after immunisation with Ad85A. • Protection against Mtb challenge induced by Ad85A is abolished in Hh infected mice. • IL10R blockade reverses the effects of Hh infection on Ad85A induced protection. • Addition of Hh to the microbiota abolishes protection induced by a subunit vaccine.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2015.02.041