This Month in The Journal

Genome-wide association studies (GWASs) have revealed numerous variants associated with a wide variety of human traits and diseases. By their very nature, however, these studies are unable to pinpoint causal variants, thus necessitating detailed follow-up studies. These so-called post-GWAS studies employ a variety of genetic, cell biology, and molecular techniques, often reliant upon the trait of interest. In this issue, Leslie et al. present a study aimed at identifying risk alleles with a clear functional role in the etiology of nonsyndromic cleft lip with or without cleft palate (NSCL/P).