Neuroprotective activity of (1 S ,2 E ,4 R ,6 R ,-7 E ,11 E )-2,7,11-cembratriene-4,6-diol (4R) in vitro and in vivo in rodent models of brain ischemia

Highlights • Treatment with 4R reduces infarct volume in rodent ischemic stroke models. • 4R decreases apoptosis of neuroblastoma cells induced by OGD. • 4R improves the population spikes recovery in rat acute hippocampal slices in OGD. • 4R inhibits ICAM-1 expression in murine brain-derived endothe...

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Veröffentlicht in:	Neuroscience 2015-04, Vol.291, p.250-259
Hauptverfasser:	Martins, A.H, Hu, J, Xu, Z, Mu, C, Alvarez, P, Ford, B.D, El Sayed, K, Eterovic, V.A, Ferchmin, P.A, Hao, J
Format:	Artikel
Sprache:	eng
Schlagworte:	4R cembranoid Animals Brain - drug effects Brain - pathology Brain - physiopathology Brain Ischemia - drug therapy Brain Ischemia - pathology Brain Ischemia - physiopathology Cell Hypoxia - drug effects Cell Hypoxia - physiology Cell Line Cell Line, Tumor Disease Models, Animal Diterpenes - pharmacology Female Glucose - deficiency inflammation intercellular adhesion molecule-1 ischemia Male Mice Neurology neuroprotection Neuroprotective Agents - pharmacology Nicotiana oxygen–glucose deprivation Rats Rats, Sprague-Dawley Stroke - drug therapy Stroke - pathology Stroke - physiopathology
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Zusammenfassung:	Highlights • Treatment with 4R reduces infarct volume in rodent ischemic stroke models. • 4R decreases apoptosis of neuroblastoma cells induced by OGD. • 4R improves the population spikes recovery in rat acute hippocampal slices in OGD. • 4R inhibits ICAM-1 expression in murine brain-derived endothelial cells. • 4R restores Akt phosphorylation in murine brain-derived endothelial cells in OGD.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2015.02.001