Doxycycline loaded poly(ethylene glycol) hydrogels for healing vesicant-induced ocular wounds

Abstract Half mustard (CEES) and nitrogen mustard (NM) are commonly used surrogates and vesicant analogs of the chemical warfare agent sulfur mustard. In the current study, in situ forming poly(ethylene glycol) (PEG)-based doxycycline hydrogels are developed and evaluated for their wound healing eff...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biomaterials 2010-02, Vol.31 (5), p.964-974
Hauptverfasser:	Anumolu, SivaNaga S, DeSantis, Andrea S, Menjoge, Anupa R, Hahn, Rita A, Beloni, John A, Gordon, Marion K, Sinko, Patrick J
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Animals Anti-Bacterial Agents - administration & dosage Cornea organ culture model Dentistry Doxycycline Doxycycline - administration & dosage Doxycycline - chemistry Drug Carriers - chemistry Eye Burns - chemically induced Eye Burns - drug therapy Hydrogel Hydrogels - chemistry Irritants - poisoning Materials Testing Nitrogen Mustard Compounds - poisoning Ocular drug delivery Poly(ethylene glycol) Polyethylene Glycols - chemistry Rabbits Sustained release Treatment Outcome Wound Healing - drug effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Abstract Half mustard (CEES) and nitrogen mustard (NM) are commonly used surrogates and vesicant analogs of the chemical warfare agent sulfur mustard. In the current study, in situ forming poly(ethylene glycol) (PEG)-based doxycycline hydrogels are developed and evaluated for their wound healing efficacy in CEES and NM-exposed rabbit corneas in organ culture. The hydrogels, characterized by UV–Vis spectrophotometry, rheometry, and swelling kinetics, showed that the hydrogels are optically transparent, have good mechanical strength and a relatively low degree of swelling (
ISSN:	0142-9612 1878-5905
DOI:	10.1016/j.biomaterials.2009.10.010