VMAT1 deletion causes neuronal loss in the hippocampus and neurocognitive deficits in spatial discrimination

Highlights ► VMAT1 is expressed in mouse brain. ► Deletion of VMAT1 results in reduced neurogenesis and apoptosis in the hippocampus. ► VMAT2 expression is not affected by VMAT1 deletion. ► Behavioral experiments show that VMAT1 KO mice have reduced spatial object recognition.

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Veröffentlicht in:	Neuroscience 2013-03, Vol.232, p.32-44
Hauptverfasser:	Multani, P.K, Hodge, R, Estévez, M.A, Abel, T, Kung, H, Alter, M, Brookshire, B, Lucki, I, Nall, A.H, Talbot, K, Doyle, G.A, Lohoff, F.W
Format:	Artikel
Sprache:	eng
Schlagworte:	Anatomical correlates of behavior Animals apoptosis Apoptosis - physiology Behavioral psychophysiology Biological and medical sciences Brain - pathology Brain - physiopathology Caspase 3 - metabolism cognition Cognition Disorders - pathology Cognition Disorders - physiopathology Conditioning (Psychology) - physiology Discrimination (Psychology) - physiology Fear - physiology Fundamental and applied biological sciences. Psychology hippocampus Male Mice, Knockout neurogenesis Neurogenesis - physiology Neurology Neurons - pathology Neurons - physiology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Recognition (Psychology) - physiology RNA, Messenger - metabolism SLC18A1 Space Perception - physiology Synaptophysin - metabolism Vesicular Monoamine Transport Proteins - deficiency Vesicular Monoamine Transport Proteins - genetics Vesicular Monoamine Transport Proteins - metabolism
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Beschreibung
Zusammenfassung:	Highlights ► VMAT1 is expressed in mouse brain. ► Deletion of VMAT1 results in reduced neurogenesis and apoptosis in the hippocampus. ► VMAT2 expression is not affected by VMAT1 deletion. ► Behavioral experiments show that VMAT1 KO mice have reduced spatial object recognition.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2012.11.023