Synapse-specific compartmentalization of signaling cascades for LTP induction in CA3 interneurons
Highlights • Recurrent commissural axons of CA3 cells contacting interneurons express LTP. • This form of LTP requires CI AMPAR and NMDARs. The blockade of NMDARs triggers LTD. • This RC LTP requires CaMKII and PKC but not PKA activity for its induction. • RC LTP can be expressed simultaneously to m...
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| Veröffentlicht in: | Neuroscience 2015-04, Vol.290, p.332-345 |
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| creator | Galván, E.J Pérez-Rosello, T Gómez-Lira, G Lara, E Gutiérrez, R Barrionuevo, G |
| description | Highlights • Recurrent commissural axons of CA3 cells contacting interneurons express LTP. • This form of LTP requires CI AMPAR and NMDARs. The blockade of NMDARs triggers LTD. • This RC LTP requires CaMKII and PKC but not PKA activity for its induction. • RC LTP can be expressed simultaneously to mossy fiber LTP on CA3 interneurons. • Aspiny dendritic trees segregate signaling cascades to bear different forms of LTP. |
| doi_str_mv | 10.1016/j.neuroscience.2015.01.024 |
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The blockade of NMDARs triggers LTD. • This RC LTP requires CaMKII and PKC but not PKA activity for its induction. • RC LTP can be expressed simultaneously to mossy fiber LTP on CA3 interneurons. • Aspiny dendritic trees segregate signaling cascades to bear different forms of LTP.</description><identifier>ISSN: 0306-4522</identifier><identifier>EISSN: 1873-7544</identifier><identifier>DOI: 10.1016/j.neuroscience.2015.01.024</identifier><identifier>PMID: 25637803</identifier><language>eng</language><publisher>United States: Elsevier Ltd</publisher><subject>Animals ; CA3 interneurons ; CA3 Region, Hippocampal - drug effects ; CA3 Region, Hippocampal - physiology ; calcium impermeable AMPARs ; Calcium-Calmodulin-Dependent Protein Kinase Type 2 - antagonists & inhibitors ; Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism ; CaMKII ; Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors ; Cyclic AMP-Dependent Protein Kinases - metabolism ; feed-forward inhibition ; Interneurons - drug effects ; Interneurons - physiology ; Long-Term Potentiation - drug effects ; Long-Term Potentiation - physiology ; Male ; Mossy Fibers, Hippocampal - drug effects ; Mossy Fibers, Hippocampal - physiology ; Neurology ; PKA ; PKC ; Protein Kinase C - antagonists & inhibitors ; Protein Kinase C - metabolism ; Rats, Sprague-Dawley ; Receptors, AMPA - antagonists & inhibitors ; Receptors, AMPA - metabolism ; Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors ; Receptors, N-Methyl-D-Aspartate - metabolism ; recurrent commissural LTP and LTD ; Synapses - drug effects ; Synapses - physiology ; Tissue Culture Techniques</subject><ispartof>Neuroscience, 2015-04, Vol.290, p.332-345</ispartof><rights>IBRO</rights><rights>2015 IBRO</rights><rights>Copyright © 2015 IBRO. All rights reserved.</rights><rights>2015 IBRO. 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Pérez-Rosello, T ; Gómez-Lira, G ; Lara, E ; Gutiérrez, R ; Barrionuevo, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c575t-1cbe9012d9f7ccc0c294b5987eba99eb1d70d981136cdca9dc2337b66297a5093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>CA3 interneurons</topic><topic>CA3 Region, Hippocampal - drug effects</topic><topic>CA3 Region, Hippocampal - physiology</topic><topic>calcium impermeable AMPARs</topic><topic>Calcium-Calmodulin-Dependent Protein Kinase Type 2 - antagonists & inhibitors</topic><topic>Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism</topic><topic>CaMKII</topic><topic>Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors</topic><topic>Cyclic AMP-Dependent Protein Kinases - metabolism</topic><topic>feed-forward inhibition</topic><topic>Interneurons - drug effects</topic><topic>Interneurons - physiology</topic><topic>Long-Term Potentiation - drug effects</topic><topic>Long-Term Potentiation - physiology</topic><topic>Male</topic><topic>Mossy Fibers, Hippocampal - drug effects</topic><topic>Mossy Fibers, Hippocampal - physiology</topic><topic>Neurology</topic><topic>PKA</topic><topic>PKC</topic><topic>Protein Kinase C - antagonists & inhibitors</topic><topic>Protein Kinase C - metabolism</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptors, AMPA - antagonists & inhibitors</topic><topic>Receptors, AMPA - metabolism</topic><topic>Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors</topic><topic>Receptors, N-Methyl-D-Aspartate - metabolism</topic><topic>recurrent commissural LTP and LTD</topic><topic>Synapses - drug effects</topic><topic>Synapses - physiology</topic><topic>Tissue Culture Techniques</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Galván, E.J</creatorcontrib><creatorcontrib>Pérez-Rosello, T</creatorcontrib><creatorcontrib>Gómez-Lira, G</creatorcontrib><creatorcontrib>Lara, E</creatorcontrib><creatorcontrib>Gutiérrez, R</creatorcontrib><creatorcontrib>Barrionuevo, G</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Galván, E.J</au><au>Pérez-Rosello, T</au><au>Gómez-Lira, G</au><au>Lara, E</au><au>Gutiérrez, R</au><au>Barrionuevo, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synapse-specific compartmentalization of signaling cascades for LTP induction in CA3 interneurons</atitle><jtitle>Neuroscience</jtitle><addtitle>Neuroscience</addtitle><date>2015-04-02</date><risdate>2015</risdate><volume>290</volume><spage>332</spage><epage>345</epage><pages>332-345</pages><issn>0306-4522</issn><eissn>1873-7544</eissn><abstract>Highlights • Recurrent commissural axons of CA3 cells contacting interneurons express LTP. • This form of LTP requires CI AMPAR and NMDARs. The blockade of NMDARs triggers LTD. • This RC LTP requires CaMKII and PKC but not PKA activity for its induction. • RC LTP can be expressed simultaneously to mossy fiber LTP on CA3 interneurons. • Aspiny dendritic trees segregate signaling cascades to bear different forms of LTP.</abstract><cop>United States</cop><pub>Elsevier Ltd</pub><pmid>25637803</pmid><doi>10.1016/j.neuroscience.2015.01.024</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals CA3 interneurons CA3 Region, Hippocampal - drug effects CA3 Region, Hippocampal - physiology calcium impermeable AMPARs Calcium-Calmodulin-Dependent Protein Kinase Type 2 - antagonists & inhibitors Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism CaMKII Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors Cyclic AMP-Dependent Protein Kinases - metabolism feed-forward inhibition Interneurons - drug effects Interneurons - physiology Long-Term Potentiation - drug effects Long-Term Potentiation - physiology Male Mossy Fibers, Hippocampal - drug effects Mossy Fibers, Hippocampal - physiology Neurology PKA PKC Protein Kinase C - antagonists & inhibitors Protein Kinase C - metabolism Rats, Sprague-Dawley Receptors, AMPA - antagonists & inhibitors Receptors, AMPA - metabolism Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Receptors, N-Methyl-D-Aspartate - metabolism recurrent commissural LTP and LTD Synapses - drug effects Synapses - physiology Tissue Culture Techniques |
| title | Synapse-specific compartmentalization of signaling cascades for LTP induction in CA3 interneurons |
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