Synapse-specific compartmentalization of signaling cascades for LTP induction in CA3 interneurons

Highlights • Recurrent commissural axons of CA3 cells contacting interneurons express LTP. • This form of LTP requires CI AMPAR and NMDARs. The blockade of NMDARs triggers LTD. • This RC LTP requires CaMKII and PKC but not PKA activity for its induction. • RC LTP can be expressed simultaneously to m...

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Veröffentlicht in:	Neuroscience 2015-04, Vol.290, p.332-345
Hauptverfasser:	Galván, E.J, Pérez-Rosello, T, Gómez-Lira, G, Lara, E, Gutiérrez, R, Barrionuevo, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CA3 interneurons CA3 Region, Hippocampal - drug effects CA3 Region, Hippocampal - physiology calcium impermeable AMPARs Calcium-Calmodulin-Dependent Protein Kinase Type 2 - antagonists & inhibitors Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism CaMKII Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors Cyclic AMP-Dependent Protein Kinases - metabolism feed-forward inhibition Interneurons - drug effects Interneurons - physiology Long-Term Potentiation - drug effects Long-Term Potentiation - physiology Male Mossy Fibers, Hippocampal - drug effects Mossy Fibers, Hippocampal - physiology Neurology PKA PKC Protein Kinase C - antagonists & inhibitors Protein Kinase C - metabolism Rats, Sprague-Dawley Receptors, AMPA - antagonists & inhibitors Receptors, AMPA - metabolism Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Receptors, N-Methyl-D-Aspartate - metabolism recurrent commissural LTP and LTD Synapses - drug effects Synapses - physiology Tissue Culture Techniques
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Zusammenfassung:	Highlights • Recurrent commissural axons of CA3 cells contacting interneurons express LTP. • This form of LTP requires CI AMPAR and NMDARs. The blockade of NMDARs triggers LTD. • This RC LTP requires CaMKII and PKC but not PKA activity for its induction. • RC LTP can be expressed simultaneously to mossy fiber LTP on CA3 interneurons. • Aspiny dendritic trees segregate signaling cascades to bear different forms of LTP.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2015.01.024