Increased fragmentation of sleep–wake cycles in the 5XFAD mouse model of Alzheimer’s disease

Increased fragmentation of sleep–wake cycles in the 5XFAD mouse model of Alzheimer’s disease

Highlights • AD patients have disturbed sleep, including increased sleep fragmentation. • Sleep and wake patterns in 5XFAD mice, a model of AD, were examined. • 5XFAD mice of both sexes were found to have reduced sleep bout lengths. • Female 5XFAD were more severely affected, and had reduced total s...

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Veröffentlicht in:Neuroscience 2015-04, Vol.290, p.80-89
Hauptverfasser: Sethi, M, Joshi, S.S, Webb, R.L, Beckett, T.L, Donohue, K.D, Murphy, M.P, O’Hara, B.F, Duncan, M.J
Format: Artikel
Sprache:eng
Schlagworte:
Alzheimer Disease - physiopathology
amyloid beta
Amyloid beta-Protein Precursor - genetics
Amyloid beta-Protein Precursor - metabolism
Animals
Disease Models, Animal
diurnal rhythm
Female
Homeostasis - physiology
Humans
Male
Mice, Transgenic
Neurology
Presenilin-1 - genetics
Presenilin-1 - metabolism
Sex Characteristics
sleep
Sleep - physiology
Sleep Deprivation - physiopathology
sleep fragmentation
sleep homeostasis
Time Factors
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Zusammenfassung:Highlights • AD patients have disturbed sleep, including increased sleep fragmentation. • Sleep and wake patterns in 5XFAD mice, a model of AD, were examined. • 5XFAD mice of both sexes were found to have reduced sleep bout lengths. • Female 5XFAD were more severely affected, and had reduced total sleep as well. • Sleep alterations in 5XFAD mice may be relevant to human AD sleep disturbances.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2015.01.035