Alagebrium in combination with exercise ameliorates age-associated ventricular and vascular stiffness

Advanced glycation end-products (AGEs) initiate cellular inflammation and contribute to cardiovascular disease in the elderly. AGE can be inhibited by Alagebrium (ALT), an AGE cross-link breaker. Moreover, the beneficial effects of exercise on aging are well recognized. Thus, we investigated the eff...

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Veröffentlicht in:	Experimental gerontology 2012-08, Vol.47 (8), p.565-572
Hauptverfasser:	Steppan, Jochen, Tran, Huang, Benjo, Alexandre M., Pellakuru, Laxsmi, Barodka, Viachaslau, Ryoo, Sungwoo, Nyhan, Sineád M., Lussman, Craig, Gupta, Gaurav, White, Anthony R., Daher, Joao P., Shoukas, Artin A., Levine, Benjamin D., Berkowitz, Dan E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced glycation end-products AGE Aging - physiology Alagebrium Animals Diastole - physiology Drug Evaluation, Preclinical - methods Exercise Glycation End Products, Advanced - antagonists & inhibitors Glycation End Products, Advanced - metabolism Hemodynamics - physiology Male Physical Conditioning, Animal - physiology Rats Rats, Inbred F344 Systole - physiology Thiazoles - pharmacology Vascular Stiffness - drug effects Vascular Stiffness - physiology Ventricular Function, Left - drug effects Ventricular Function, Left - physiology Ventricular–vascular coupling
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Zusammenfassung:	Advanced glycation end-products (AGEs) initiate cellular inflammation and contribute to cardiovascular disease in the elderly. AGE can be inhibited by Alagebrium (ALT), an AGE cross-link breaker. Moreover, the beneficial effects of exercise on aging are well recognized. Thus, we investigated the effects of ALT and exercise (Ex) on cardiovascular function in a rat aging model. Compared to young (Y) rats, in sedentary old (O) rats, end-systolic elastance (Ees) decreased (0.9±0.2 vs 1.7±0.4mmHg/μL, P
ISSN:	0531-5565 1873-6815
DOI:	10.1016/j.exger.2012.04.006