Factors influencing culture positivity in pyogenic vertebral osteomyelitis patients with prior antibiotic exposure
We conducted a retrospective cohort study to evaluate factors influencing tissue culture positivity in patients with pyogenic vertebral osteomyelitis exposed to antibiotics before diagnosis. Tissue culture was positive in 48.3% (28/58) of the patients, and the median antibiotic-free period was 1.5 d...
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Veröffentlicht in: | Antimicrobial agents and chemotherapy 2015-04, Vol.59 (4), p.2470-2473 |
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Sprache: | eng |
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Zusammenfassung: | We conducted a retrospective cohort study to evaluate factors influencing tissue culture positivity in patients with pyogenic vertebral osteomyelitis exposed to antibiotics before diagnosis. Tissue culture was positive in 48.3% (28/58) of the patients, and the median antibiotic-free period was 1.5 days (range, 0.7 to 5.7 days). In a multivariate analysis, a higher C-reactive protein (CRP) level (adjusted odds ratio [aOR], 1.18; 95% confidence interval, 1.07 to 1.29) and open surgical biopsy (aOR, 6.33; 95% confidence interval, 1.12 to 35.86) were associated with tissue culture positivity. |
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ISSN: | 0066-4804 1098-6596 |
DOI: | 10.1128/AAC.04949-14 |