Aurora kinase A has a significant role as a therapeutic target and clinical biomarker in endometrial cancer

Aurora kinase A (AURKA) regulates the cell cycle checkpoint and maintains genomic integrity. AURKA is overexpressed in various malignant tumors and its upregulation induces chromosomal instability, which leads to aneuploidy and cell transformation. To investigate the role of AURKA in endometrial can...

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Veröffentlicht in:	International journal of oncology 2015-04, Vol.46 (4), p.1498-1506
Hauptverfasser:	UMENE, KIYOKO, YANOKURA, MEGUMI, BANNO, KOUJI, IRIE, HARUKO, ADACHI, MASATAKA, IIDA, MIHO, NAKAMURA, KANAKO, NOGAMI, YUYA, MASUDA, KENTA, KOBAYASHI, YUSUKE, TOMINAGA, EIICHIRO, AOKI, DAISUKE
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents, Phytogenic - administration & dosage Antineoplastic Agents, Phytogenic - therapeutic use Aurora kinase A Aurora Kinase A - antagonists & inhibitors Aurora Kinase A - metabolism Biological markers Cell Line, Tumor chemosensitivity Disease-Free Survival Drug targeting Drug therapy Endometrial cancer Endometrial Neoplasms - drug therapy Endometrial Neoplasms - enzymology Endometrial Neoplasms - pathology Estrogens Female Gene Knockdown Techniques Health aspects Humans Identification and classification Kinases Methods Mice Mutation Ovarian cancer paclitaxel Paclitaxel - administration & dosage Paclitaxel - therapeutic use Phosphotransferases RNA, Small Interfering - administration & dosage RNA, Small Interfering - pharmacology Up-Regulation - drug effects Xenograft Model Antitumor Assays
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Zusammenfassung:	Aurora kinase A (AURKA) regulates the cell cycle checkpoint and maintains genomic integrity. AURKA is overexpressed in various malignant tumors and its upregulation induces chromosomal instability, which leads to aneuploidy and cell transformation. To investigate the role of AURKA in endometrial cancer, we evaluated the association of immunohistochemical expression of AURKA with clinicopathological factors. Furthermore, we examined the effects of AURKA inhibition by transfected siRNA in HEC-1B cells on colony-forming ability, invasion and migration capacity, and chemosensitivity. Immunohistochemical staining showed that overexpression of AURKA was significantly associated with tumor grade (P
ISSN:	1019-6439 1791-2423
DOI:	10.3892/ijo.2015.2842