Transient Receptor Potential Channels and Their Role in Modulating Radial Glial–Neuronal Interaction: A Signaling Pathway Involving mGluR5

Transient Receptor Potential Channels and Their Role in Modulating Radial Glial–Neuronal Interaction: A Signaling Pathway Involving mGluR5

The guidance of developing neurons to the right position in the central nervous system is of central importance in brain development. Canonical transient receptor potential (TRPC) channels are thought to mediate turning responses of growth cones to guidance cues through fine control of calcium trans...

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Veröffentlicht in:Stem cells and development 2015-03, Vol.24 (6), p.71-713
Hauptverfasser: Louhivuori, Lauri M., Jansson, Linda, Turunen, Pauli M., Jäntti, Maria H., Nordström, Tommy, Louhivuori, Verna, Åkerman, Karl E.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cell Movement
Cells, Cultured
Ependymoglial Cells - cytology
Ependymoglial Cells - metabolism
Mice
Mice, Inbred C57BL
Neural Stem Cells - cytology
Neural Stem Cells - metabolism
Neurogenesis
Neurons - cytology
Neurons - metabolism
Original Research Reports
Receptor, Metabotropic Glutamate 5 - antagonists & inhibitors
Receptor, Metabotropic Glutamate 5 - genetics
Receptor, Metabotropic Glutamate 5 - metabolism
Signal Transduction
TRPC Cation Channels - genetics
TRPC Cation Channels - metabolism
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Zusammenfassung:The guidance of developing neurons to the right position in the central nervous system is of central importance in brain development. Canonical transient receptor potential (TRPC) channels are thought to mediate turning responses of growth cones to guidance cues through fine control of calcium transients. Proliferating and 1- to 5-day-differentiated neural progenitor cells (NPCs) showed expression of Trpc1 and Trpc3 mRNA, while Trpc4–7 was not clearly detected. Time-lapse imaging showed that the motility pattern of neuronal cells was phasic with bursts of rapid movement (>60 μm/h), changes in direction, and intermittent slow phases or stallings (
ISSN:1547-3287
1557-8534
DOI:10.1089/scd.2014.0209