DNA end binding activity and Ku70/80 heterodimer expression in human colorectal tumor

To determine the DNA binding activity and protein levels of the Ku70/80 heterodimer, the functional mediator of the NHEJ activity, in human colorectal carcinogenesis. The Ku70/80 DNA-binding activity was determined by electrophoretic mobility shift assays in 20 colon adenoma and 15 colorectal cancer...

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Veröffentlicht in:	World journal of gastroenterology : WJG 2005-11, Vol.11 (42), p.6694-6700
Hauptverfasser:	Mazzarelli, Paola, Parrella, Paola, Seripa, Davide, Signori, Emanuela, Perrone, Giuseppe, Rabitti, Carla, Borzomati, Domenico, Gabbrielli, Armando, Matera, Maria Giovanna, Gravina, Carolina, Caricato, Marco, Poeta, Maria Luana, Rinaldi, Monica, Valeri, Sergio, Coppola, Roberto, Fazio, Vito Michele
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoma - genetics Adenoma - metabolism Adenoma - pathology Adult Aged Aged, 80 and over Antigens, Nuclear - chemistry Antigens, Nuclear - metabolism Brief Reports Carcinoma - genetics Carcinoma - metabolism Carcinoma - pathology Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Dimerization DNA - metabolism DNA-Activated Protein Kinase - metabolism DNA-Binding Proteins - chemistry DNA-Binding Proteins - metabolism Female Humans Immunohistochemistry Ku Autoantigen Male Middle Aged Nuclear Proteins - metabolism
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