De novo pulmonary small cell carcinomas and large cell neuroendocrine carcinomas harboring EGFR mutations: Lack of response to EGFR inhibitors

Highlights • EGFR mutations occur in some high-grade neuroendocrine lung cancers. • EGFR protein is not expressed in EGFR mutated neuroendocrine lung cancers. • Patients with neuroendocrine lung cancers don’t respond to EGFR inhibitors.

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Bibliographische Detailangaben
Veröffentlicht in:	Lung cancer (Amsterdam, Netherlands) Netherlands), 2015-04, Vol.88 (1), p.70-73
Hauptverfasser:	Le, Xiuning, Desai, Neelam V, Majid, Adnan, Karp, Rebecca S, Huberman, Mark S, Rangachari, Deepa, Kent, Michael S, Gangadharan, Sidharta P, Folch, Erik, VanderLaan, Paul A, Costa, Daniel B
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Carboplatin - pharmacology Carboplatin - therapeutic use Carcinoma, Neuroendocrine - diagnostic imaging Carcinoma, Neuroendocrine - drug therapy Carcinoma, Neuroendocrine - genetics Disease Progression Drug Resistance, Neoplasm ErbB Receptors - antagonists & inhibitors ErbB Receptors - genetics Erlotinib Hydrochloride - pharmacology Erlotinib Hydrochloride - therapeutic use Etoposide - pharmacology Etoposide - therapeutic use Fatal Outcome Female Hematology, Oncology and Palliative Medicine Humans Lung Neoplasms - diagnostic imaging Lung Neoplasms - drug therapy Lung Neoplasms - genetics Male Middle Aged Mutation Pulmonary/Respiratory Radiography Small Cell Lung Carcinoma - diagnostic imaging Small Cell Lung Carcinoma - drug therapy Small Cell Lung Carcinoma - genetics
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Beschreibung
Zusammenfassung:	Highlights • EGFR mutations occur in some high-grade neuroendocrine lung cancers. • EGFR protein is not expressed in EGFR mutated neuroendocrine lung cancers. • Patients with neuroendocrine lung cancers don’t respond to EGFR inhibitors.
ISSN:	0169-5002 1872-8332
DOI:	10.1016/j.lungcan.2015.02.003