Long-term effect of specific treatment of primary aldosteronism on carotid intima-media thickness

Aldosterone has been shown to substantially contribute to the accumulation of different types of collagen fibres and growth factors in the arterial wall, thus increasing wall thickness. A previous study showed reduction of increased common carotid intima-media thickness (IMT) in patients with primar...

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Veröffentlicht in:Journal of hypertension 2015-04, Vol.33 (4), p.874-882
Hauptverfasser: Holaj, Robert, Rosa, Ján, Zelinka, Tomáš, Štrauch, Branislav, Petrák, Ondřej, Indra, Tomáš, Šomlóová, Zuzana, Michalský, David, Novák, Květoslav, Wichterle, Dan, Widimský, Jr, Jiří
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Sprache:eng
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Zusammenfassung:Aldosterone has been shown to substantially contribute to the accumulation of different types of collagen fibres and growth factors in the arterial wall, thus increasing wall thickness. A previous study showed reduction of increased common carotid intima-media thickness (IMT) in patients with primary aldosteronism 1 year after adrenalectomy. Our study in patients with primary aldosteronism was aimed at comparing the long-term effect of adrenalectomy vs. spironolactone therapy on common carotid IMT regression. Forty-two patients with confirmed primary aldosteronism (21 with aldosterone-producing adenoma treated by unilateral laparoscopic adrenalectomy, 21 treated with spironolactone) were investigated by carotid ultrasound at baseline and 1 and 6 years after the specific treatment. There was a decrease in common carotid IMT from 0.956 ± 0.140 to 0.900 ± 0.127 mm (-5.9%; P 
ISSN:0263-6352
1473-5598
DOI:10.1097/HJH.0000000000000464