SQSTM1/p62 regulates the expression of junctional proteins through epithelial-mesenchymal transition factors

The epithelial to mesenchymal transition (EMT) is an essential process during development and during tumor progression. Here, we observed the accumulation of the selective autophagy receptor and signaling adaptor sequestosome-1 (SQSTM1/p62) during growth factor-induced EMT in immortalized and tumor-...

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Veröffentlicht in:	Cell cycle (Georgetown, Tex.) Tex.), 2015-02, Vol.14 (3), p.364-374
Hauptverfasser:	Bertrand, Matthieu, Petit, Valérie, Jain, Ashish, Amsellem, Raymonde, Johansen, Terje, Larue, Lionel, Codogno, Patrice, Beau, Isabelle
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - chemistry Adaptor Proteins, Signal Transducing - metabolism Animals Autophagy Cell Line Dogs Epithelial-Mesenchymal Transition Humans Intercellular Junctions - metabolism Mice Mutant Proteins - metabolism Protein Stability Protein Structure, Tertiary Rats Signal Transduction
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Zusammenfassung:	The epithelial to mesenchymal transition (EMT) is an essential process during development and during tumor progression. Here, we observed the accumulation of the selective autophagy receptor and signaling adaptor sequestosome-1 (SQSTM1/p62) during growth factor-induced EMT in immortalized and tumor-derived epithelial cell lines. Modulation of the p62 level regulated the expression of junctional proteins. This effect was dependent on the ubiquitin-associated domain of p62, which stabilized the TGFβ/Smad signaling co-activator Smad4 and the EMT transcription factor Twist. This study highlights a novel function of p62 in a major epithelial phenotypic alteration.
ISSN:	1538-4101 1551-4005
DOI:	10.4161/15384101.2014.987619