Use of Adipose-Derived Mesenchymal Stem Cells in Keratoconjunctivitis Sicca in a Canine Model

Keratoconjunctivitis sicca (KCS) or dry eye disease (DED) is an immune-mediated multifactorial disease, with high level of prevalence in humans and dogs. Our aim in this study was to investigate the therapeutic effects of allogeneic adipose-derived mesenchymal stromal cells (Ad-MSCs) implanted aroun...

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Veröffentlicht in:	BioMed research international 2015-01, Vol.2015 (2015), p.1-10
Hauptverfasser:	Becerra, José, Rico-Llanos, Gustavo A., Claros, Silvia, Fernández, Viviana, Villatoro, Antonio J., Andrades, José A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - cytology Animals Cell Differentiation Cell Lineage Cell Proliferation Cell Separation Cell Shape Cells, Cultured Disease Models, Animal Dogs Eye - pathology Eye diseases Female Flow Cytometry Health aspects Humans Immune system Keratoconjunctivitis Sicca - pathology Keratoconjunctivitis Sicca - therapy Male Medical treatment Mesenchymal Stem Cell Transplantation Mesenchymal Stromal Cells - cytology Physiological aspects Stem cells
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Zusammenfassung:	Keratoconjunctivitis sicca (KCS) or dry eye disease (DED) is an immune-mediated multifactorial disease, with high level of prevalence in humans and dogs. Our aim in this study was to investigate the therapeutic effects of allogeneic adipose-derived mesenchymal stromal cells (Ad-MSCs) implanted around the lacrimal glands in 12 dogs (24 eyes) with KCS, which is refractory to current available treatments. Schirmer tear test (STT) and ocular surface integrity were assessed at 0 (before treatment), 3, 6, and 9 months after treatment. Average STT values and all clinical signs showed a statistically significant change (P
ISSN:	2314-6133 2314-6141
DOI:	10.1155/2015/527926