Long-range epigenetic regulation is conferred by genetic variation located at thousands of independent loci

Long-range epigenetic regulation is conferred by genetic variation located at thousands of independent loci

The interplay between genetic and epigenetic variation is only partially understood. One form of epigenetic variation is methylation at CpG sites, which can be measured as methylation quantitative trait loci (meQTL). Here we report that in a panel of lymphocytes from 1,748 individuals, methylation l...

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Veröffentlicht in:Nature communications 2015-02, Vol.6 (1), p.6326-6326, Article 6326
Hauptverfasser: Lemire, Mathieu, Zaidi, Syed H.E., Ban, Maria, Ge, Bing, Aïssi, Dylan, Germain, Marine, Kassam, Irfahan, Wang, Mike, Zanke, Brent W., Gagnon, France, Morange, Pierre-Emmanuel, Trégouët, David-Alexandre, Wells, Philip S., Sawcer, Stephen, Gallinger, Steven, Pastinen, Tomi, Hudson, Thomas J.
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Sprache:eng
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Autoimmune Diseases - genetics
Biochemistry, Molecular Biology
Case-Control Studies
Colonic Neoplasms - genetics
Colorectal cancer
CpG Islands
Datasets
Disease
DNA Methylation
Epigenesis, Genetic
Epigenetics
Gene loci
Genetics
Genomes
Genomics
Genotype
Hospitals
Human genetics
Humanities and Social Sciences
Humans
Life Sciences
Lymphocytes
Medical research
Molecular biology
multidisciplinary
Nutrition
Polymorphism, Single Nucleotide
Quantitative Trait Loci
Science
Science (multidisciplinary)
Thrombosis
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Zusammenfassung:The interplay between genetic and epigenetic variation is only partially understood. One form of epigenetic variation is methylation at CpG sites, which can be measured as methylation quantitative trait loci (meQTL). Here we report that in a panel of lymphocytes from 1,748 individuals, methylation levels at 1,919 CpG sites are correlated with at least one distal ( trans ) single-nucleotide polymorphism (SNP) ( P
ISSN:2041-1723
2041-1723
DOI:10.1038/ncomms7326