Diagnosis of Neuroinvasive Astrovirus Infection in an Immunocompromised Adult With Encephalitis by Unbiased Next-Generation Sequencing

Diagnosis of Neuroinvasive Astrovirus Infection in an Immunocompromised Adult With Encephalitis by Unbiased Next-Generation Sequencing

Metagenomic next-generation sequencing (NGS) was used to diagnose an unusual and fatal case of progressive encephalitis in an immunocompromised adult presenting at disease onset as bilateral hearing loss. The sequencing and confirmatory studies revealed neuroinvasive infection of the brain by an ast...

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Veröffentlicht in:Clinical infectious diseases 2015-03, Vol.60 (6), p.919-923
Hauptverfasser: Naccache, Samia N., Peggs, Karl S., Mattes, Frank M., Phadke, Rahul, Garson, Jeremy A., Grant, Paul, Samayoa, Erik, Federman, Scot, Miller, Steve, Lunn, Michael P., Gant, Vanya, Chiu, Charles Y.
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Astroviridae Infections - diagnosis
Brain
Brain - pathology
BRIEF REPORTS
Capsid Proteins - genetics
Encephalitis
Encephalitis, Viral - complications
Encephalitis, Viral - diagnosis
Fatal Outcome
Hearing loss
Hearing Loss, Bilateral - etiology
High-Throughput Nucleotide Sequencing - methods
Humans
Infectious diseases
Leukemia, Lymphoid - complications
Mamastrovirus - genetics
Mamastrovirus - isolation & purification
Phylogeny
Viruses
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Zusammenfassung:Metagenomic next-generation sequencing (NGS) was used to diagnose an unusual and fatal case of progressive encephalitis in an immunocompromised adult presenting at disease onset as bilateral hearing loss. The sequencing and confirmatory studies revealed neuroinvasive infection of the brain by an astrovirus belonging to a recently discovered VA/HMO clade.
ISSN:1058-4838
1537-6591
DOI:10.1093/cid/ciu912