A multimeric MR-optical contrast agent for multimodal imaging

We describe the design, synthesis and in vitro evaluation of a multimodal and multimeric contrast agent. The agent consists of three macrocyclic Gd(III) chelates conjugated to a fluorophore and possesses high relaxivity, water solubility, and is nontoxic. The modular synthesis is amenable for the in...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2014-10, Vol.50 (78), p.11469-11471
Hauptverfasser:	Harrison, Victoria S R, Carney, Christiane E, Macrenaris, Keith W, Meade, Thomas J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line, Tumor Chelates Chelating Agents - chemistry Chemical compounds chemical reactions Contrast agents Contrast Media - chemical synthesis Contrast Media - chemistry Contrast Media - metabolism Coordination Complexes - chemical synthesis Coordination Complexes - chemistry Coordination Complexes - metabolism Fluorescence fluorescent dyes Fluorescent Dyes - chemistry gadolinium Gadolinium - chemistry HeLa Cells Humans image analysis in vitro studies Magnetic Resonance Imaging Mice Microscopy, Confocal Modular construction Optical Imaging Solubility Synthesis Synthesis (chemistry) water solubility
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Beschreibung
Zusammenfassung:	We describe the design, synthesis and in vitro evaluation of a multimodal and multimeric contrast agent. The agent consists of three macrocyclic Gd(III) chelates conjugated to a fluorophore and possesses high relaxivity, water solubility, and is nontoxic. The modular synthesis is amenable for the incorporation of a variety of fluorophores to generate molecular constructs for a number of applications.
ISSN:	1359-7345 1364-548X 1364-548X
DOI:	10.1039/c4cc05651e