A Bacterial Mutant Library as a Tool to Study the Attack of a Defensin Peptide

Defensin attack! Here we report the screening of human defensin 5 against the Keio Collection of E. coli strains. The results of this screen further our understanding of how this important hostdefense peptide kills bacteria and how bacteria protect themselves against the attack from the human host.

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Bibliographische Detailangaben
Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2014-12, Vol.15 (18), p.2684-2688
Hauptverfasser:	Moser, Simone, Chileveru, Haritha R., Tomaras, Jill, Nolan, Elizabeth M.
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Defensins - chemistry alpha-Defensins - immunology Amino Acid Sequence Escherichia coli Escherichia coli - genetics Escherichia coli - immunology Escherichia coli - physiology Escherichia coli Infections - immunology Escherichia coli Infections - microbiology Gene Library Host-Pathogen Interactions human defensins Humans Immunity, Innate innate immunity Keio Collection knockout mutants lipopolysaccharide Models, Molecular Molecular Sequence Data Mutation
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Beschreibung
Zusammenfassung:	Defensin attack! Here we report the screening of human defensin 5 against the Keio Collection of E. coli strains. The results of this screen further our understanding of how this important hostdefense peptide kills bacteria and how bacteria protect themselves against the attack from the human host.
ISSN:	1439-4227 1439-7633
DOI:	10.1002/cbic.201402354