Hyperhomocysteinemia and MTHFR Polymorphisms as Antenatal Risk Factors of White Matter Abnormalities in Two Cohorts of Late Preterm and Full Term Newborns

Hyperhomocysteinemia and MTHFR Polymorphisms as Antenatal Risk Factors of White Matter Abnormalities in Two Cohorts of Late Preterm and Full Term Newborns

Higher total homocysteine (tHcy) levels, and C677T and A1298C methylenetetrahydrofolate (MTHFR) polymorphisms, have been reported in preterm or full term newborns with neonatal encephalopathy following perinatal hypoxic-ischemic insult. This study investigated the causal role of tHcy and MTHFR polym...

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Veröffentlicht in:Oxidative medicine and cellular longevity 2015-01, Vol.2015 (2015), p.1-8
Hauptverfasser: D’Angelo, Gabriella, Mamì, Carmelo, Di Rosa, Gabriella, Caccamo, Daniela, Alibrandi, Angela, Bonsignore, Maria, Cardile, Giovanna, Giaimo, Elisa, Salpietro, Vincenzo, Nicotera, Antonio, Marseglia, Lucia, Manti, Sara
Format: Artikel
Sprache:eng
Schlagworte:
Age
Aqueous solutions
Babies
Birth weight
Cohort Studies
Colleges & universities
Demography
Deoxyribonucleic acid
DNA
Echoencephalography
Female
Genotype
Health risk assessment
Homocysteine
Humans
Hyperhomocysteinemia - genetics
Hyperhomocysteinemia - pathology
Infant, Newborn
Infants (Newborn)
Intensive care
Laboratories
Linear Models
Male
Metabolism
Methylenetetrahydrofolate Reductase (NADPH2) - genetics
Mutation
Neuromuscular diseases
Newborn babies
Odds Ratio
Oxidative stress
Polymorphism, Genetic
Preeclampsia
Pregnancy
Pregnant women
Premature Birth
Prenatal Diagnosis
Risk Factors
Traumatic brain injury
White Matter - diagnostic imaging
White Matter - physiopathology
Womens health
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Zusammenfassung:Higher total homocysteine (tHcy) levels, and C677T and A1298C methylenetetrahydrofolate (MTHFR) polymorphisms, have been reported in preterm or full term newborns with neonatal encephalopathy following perinatal hypoxic-ischemic insult. This study investigated the causal role of tHcy and MTHFR polymorphisms together with other acquired risk factors on the occurrence of brain white matter abnormalities (WMA) detected by cranial ultrasound scans (cUS) in a population of late preterm and full term infants. A total of 171 newborns (81 M, 47.4%), 45 (26.3%) born
ISSN:1942-0900
1942-0994
1942-0994
DOI:10.1155/2015/543134