Pyrrolidine dithiocarbamate reduces the progression of total kidney volume and cyst enlargement in experimental polycystic kidney disease

Heterocyclic dithiocarbamates have anti‐inflammatory and anti‐proliferative effects in rodent models of chronic kidney disease. In this study, we tested the hypothesis that pyrrolidine dithiocarbamate (PDTC) reduces the progression of polycystic kidney disease (PKD). Male Lewis polycystic kidney (LP...

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Veröffentlicht in:	Physiological reports 2014-12, Vol.2 (12), p.e12196-n/a
Hauptverfasser:	Ta, Michelle H. T., Rao, Padmashree, Korgaonkar, Mayuresh, Foster, Sheryl F., Peduto, Anthony, Harris, David C. H., Rangan, Gopala K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Body weight Bortezomib Cell proliferation Cysts Deoxyribonucleic acid DNA Enlargement Epithelial cells Fibrosis Hypotheses Image processing Inflammation Kidney diseases Magnetic resonance imaging Mutation nuclear factor‐κB Original Research Physiology Polycystic kidney polycystic kidney disease Proteasome inhibitors Proteinuria Pyrrolidine dithiocarbamate Renal function Signal transduction Studies
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Zusammenfassung:	Heterocyclic dithiocarbamates have anti‐inflammatory and anti‐proliferative effects in rodent models of chronic kidney disease. In this study, we tested the hypothesis that pyrrolidine dithiocarbamate (PDTC) reduces the progression of polycystic kidney disease (PKD). Male Lewis polycystic kidney (LPK) rats (an ortholog of Nek8/NPHP9) received intraperitoneal injections of either saline vehicle or PDTC (40 mg/kg once or twice daily) from postnatal weeks 4 until 11. By serial magnetic resonance imaging at weeks 5 and 10, the relative within‐rat increase in total kidney volume and cyst volume were 1.3‐fold (P = 0.01) and 1.4‐fold (P
ISSN:	2051-817X 2051-817X
DOI:	10.14814/phy2.12196