Design and Synthesis of Novel Isoxazole Tethered Quinone-Amino Acid Hybrids

Design and Synthesis of Novel Isoxazole Tethered Quinone-Amino Acid Hybrids

A new series of isoxazole tethered quinone-amino acid hybrids has been designed and synthesized involving 1,3-dipolar cycloaddition reaction followed by an oxidation reaction using cerium ammonium nitrate (CAN). Using this method, for the first time various isoxazole tethered quinone-phenyl alanine...

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Veröffentlicht in:Journal of Amino Acids 2014-01, Vol.2014 (2014), p.i1-14
Hauptverfasser: Ravi Kumar, P., Behera, Manoranjan, Sambaiah, M., Kandula, Venu, Payili, Nagaraju, Jaya Shree, A., Yennam, Satyanarayana
Format: Artikel
Sprache:eng
Schlagworte:
Amino acids
Ammonium nitrate
Antibiotics
Chromatography
Natural products
Quinone
Synthesis
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Zusammenfassung:A new series of isoxazole tethered quinone-amino acid hybrids has been designed and synthesized involving 1,3-dipolar cycloaddition reaction followed by an oxidation reaction using cerium ammonium nitrate (CAN). Using this method, for the first time various isoxazole tethered quinone-phenyl alanine and quinone-alanine hybrids were synthesized from simple commercially available 4-bromobenzyl bromide, propargyl bromide, and 2,5-dimethoxybenzaldehyde in good yield.
ISSN:2090-0112
2090-0104
2090-0112
DOI:10.1155/2014/721291