Increasing Incidence of Chronic Graft-versus-Host Disease in Allogeneic Transplantation – A Report from CIBMTR

Increasing Incidence of Chronic Graft-versus-Host Disease in Allogeneic Transplantation – A Report from CIBMTR

Although transplant practices have changed over the last decades there is no information on trends in incidence and outcome of cGVHD over time. This study utilized the central database of the Center for International Blood and Marrow Transplant Research (CIBMTR) to describe the time trends for cGVHD...

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Veröffentlicht in:Biology of blood and marrow transplantation 2014-10, Vol.21 (2), p.266-274
Hauptverfasser: Arai, Sally, Arora, Mukta, Wang, Tao, Spellman, Stephen R., He, Wensheng, Couriel, Daniel R., Urbano-Ispizua, Alvaro, Cutler, Corey S., Bacigalupo, Andrea A., Battiwalla, Minoo, Flowers, Mary E., Juckett, Mark B., Lee, Stephanie J., Loren, Alison W., Klumpp, Thomas R., Prockup, Susan E., Ringdén, Olle T.H., Savani, Bipin N., Socié, Gérard, Schultz, Kirk R., Spitzer, Thomas, Teshima, Takanori, Bredeson, Christopher N., Jacobsohn, David A., Hayashi, Robert J., Drobyski, William R., Frangoul, Haydar A., Akpek, Görgün, Ho, Vincent T., Lewis, Victor A., Gale, Robert Peter, DSc(hon), Koreth, John, Chao, Nelson J., Aljurf, Mahmoud D., Cooper, Brenda W., Laughlin, Mary J., Hsu, Jack W., Hematti, Peiman, Verdonck, Leo F., Solh, Melhelm M., Norkin, Maxim, Reddy, Vijay, Martino, Rodrigo, Gadalla, Shahinaz, Goldberg, Jenna D., McCarthy, Philip L., Pérez-Simón, José A., Khera, Nandita, Lewis, Ian D., Atsuta, Yoshiko, Olsson, Richard F., Saber, Wael, Waller, Edmund K., Blaise, Didier, Pidala, Joseph A., Martin, Paul J., Satwani, Prakash, Bornhäuser, Martin, Inamoto, Yoshihiro, Weisdorf, Daniel J., Horowitz, Mary M., Pavletic, Steven Z.
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Sprache:eng
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Zusammenfassung:Although transplant practices have changed over the last decades there is no information on trends in incidence and outcome of cGVHD over time. This study utilized the central database of the Center for International Blood and Marrow Transplant Research (CIBMTR) to describe the time trends for cGVHD incidence, non-relapse mortality, and the risk factors for cGVHD. The 12-year period was divided into three intervals: 1995-1999, 2000-2003, 2004-2007, and included 26,563 patients with acute leukemia, chronic myeloid leukemia and myelodysplastic syndrome. In the multivariate analysis, the incidence of cGVHD was shown to be increased in more recent years (odds ratio= 1.19, p
ISSN:1083-8791
1523-6536
DOI:10.1016/j.bbmt.2014.10.021