Increased gluconeogenesis in youth with newly diagnosed type 2 diabetes

Aims/hypothesis The role of increased gluconeogenesis as an important contributor to fasting hyperglycaemia at diabetes onset is not known. We evaluated the contribution of gluconeogenesis and glycogenolysis to fasting hyperglycaemia in newly diagnosed youths with type 2 diabetes following an overnight fast. Methods Basal rates (μmol kg FFM −1 min −1 ) of gluconeogenesis ( 2 H 2 O), glycogenolysis and glycerol production ([ 2 H 5 ] glycerol) were measured in 18 adolescents (nine treatment naive diabetic and nine normal-glucose-tolerant obese adolescents). Results Type 2 diabetes was associated with higher gluconeogenesis (9.2 ± 0.6 vs 7.0 ± 0.3 μmol kg FFM −1 min −1 , p