Local N-methyl- d -aspartate receptor antagonism in the prefrontal cortex attenuates spatial cognitive deficits induced by gonadectomy in adult male rats

Highlights • NMDA receptor block in the prefrontal cortex impairs Barnes maze performance in male rats. • NMDA receptor block in the prefrontal cortex improved cognition in gonadectomized rats. • Estrogen and androgen modulate cognition through NMDA receptors in the prefrontal cortex.

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Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2015-03, Vol.288, p.73-85
Hauptverfasser:	Locklear, M.N, Bhamidipaty, S, Kritzer, M.F
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Amino-5-phosphonovalerate - pharmacology androgen Animals Barnes maze Cognition Disorders - drug therapy Cognition Disorders - physiopathology Estradiol - administration & dosage estrogen Excitatory Amino Acid Antagonists - pharmacology executive function Hormones - administration & dosage Male Maze Learning - drug effects Maze Learning - physiology Neurology Orchiectomy Prefrontal Cortex - drug effects Prefrontal Cortex - physiopathology Rats, Sprague-Dawley Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Receptors, N-Methyl-D-Aspartate - metabolism schizophrenia Testosterone Propionate - administration & dosage working memory
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Beschreibung
Zusammenfassung:	Highlights • NMDA receptor block in the prefrontal cortex impairs Barnes maze performance in male rats. • NMDA receptor block in the prefrontal cortex improved cognition in gonadectomized rats. • Estrogen and androgen modulate cognition through NMDA receptors in the prefrontal cortex.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2014.12.032