Age-dependent long-term structural and functional effects of early-life seizures: Evidence for a hippocampal critical period influencing plasticity in adulthood

Highlights • Age at time of postnatal seizures has distinctive effects in adult hippocampus. • Early-life seizures prominently modify hippocampal development. • Postnatal days 20–30 are identified as a critical period in hippocampal development.

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Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2015-03, Vol.288, p.120-134
Hauptverfasser:	Sayin, U, Hutchinson, E, Meyerand, M.E, Sutula, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Atrophy Corpus Callosum - growth & development Corpus Callosum - pathology Corpus Callosum - physiopathology critical periods dentate gyrus developmental plasticity Diffusion Tensor Imaging Disease Models, Animal epilepsy Female hippocampus Hippocampus - growth & development Hippocampus - pathology Hippocampus - physiopathology Hyperthermia, Induced in vivo imaging Kainic Acid Kindling, Neurologic - physiology Magnetic Resonance Imaging Male Neural Pathways - growth & development Neural Pathways - pathology Neural Pathways - physiopathology Neurology Pentylenetetrazole Rats, Sprague-Dawley Seizures - pathology Seizures - physiopathology
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Beschreibung
Zusammenfassung:	Highlights • Age at time of postnatal seizures has distinctive effects in adult hippocampus. • Early-life seizures prominently modify hippocampal development. • Postnatal days 20–30 are identified as a critical period in hippocampal development.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2014.12.017