miRNA expression atlas in male rat

MicroRNAs (miRNAs) are small (~22 nucleotide) noncoding RNAs that play pivotal roles in regulation of gene expression. The value of miRNAs as circulating biomarkers is now broadly recognized; such tissue-specific biomarkers can be used to monitor tissue injury and several pathophysiological conditions in organs. In addition, miRNA profiles of normal organs and tissues are important for obtaining a better understanding of the source of modulated miRNAs in blood and how those modulations reflect various physiological and toxicological conditions. This work was aimed at creating an miRNA atlas in rats, as part of a collaborative effort with the Toxicogenomics Informatics Project in Japan (TGP2). We analyzed genome-wide miRNA profiles of 55 different organs and tissues obtained from normal male rats using miRNA arrays. The work presented herein represents a comprehensive dataset derived from normal samples profiled in a single study. Here we present the whole dataset with miRNA profiles of multiple organs, as well as precise information on experimental procedures and organ-specific miRNAs identified in this dataset. Design Type(s) microRNA profiling by array design • organism part comparison design Measurement Type(s) microRNA profiling assay Technology Type(s) DNA microarray Factor Type(s) Organism Part • saline perfusion Sample Characteristic(s) Rattus norvegicus • liver • kidney • lung • cardiac atrium • interventricular septum • skin of body • cervical lymph node • mesenteric lymph node • sublingual gland • gland • parotid gland • thymus • trachea • thyroid gland • tongue • esophagus • forestomach • stomach glandular region • duodenum • jejunum • ileum • caecum • colon • rectum • pancreas • spleen • adrenal gland • urinary bladder • seminal vesicle • prostate gland ventral lobe • reproductive system • testis • epididymis • eye • Harderian gland • optic nerve • cerebral cortex • hippocampus • thalamus • cerebellum • medulla oblongata • Pituitary gland • cervical spinal cord • nervous system • lumbar spinal cord • femoral muscle • gastrocnemius • soleus muscle • muscle • bone marrow • aorta • vein • white adipose tissue • brown adipose tissue Machine-accessible metadata file describing the reported data (ISA-Tab format)