Performance of the fourth-generation Bio-Rad GS HIV Combo Ag/Ab enzyme immunoassay for diagnosis of HIV infection in Southern Africa

Highlights • The sensitivity of the Bio-Rad Combo assay was 100% (95% confidence interval [CI]: 98.8–100%) in this African cohort. • The specificity of the Bio-Rad Combo assay was 96.7% (95% CI: 94.0–98.4%)) in this African cohort. • The Bio-Rad Combo assay identified acute/early HIV infections....

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Veröffentlicht in:	Journal of clinical virology 2015-01, Vol.62, p.75-79
Hauptverfasser:	Piwowar-Manning, Estelle, Fogel, Jessica M, Richardson, Paul, Wolf, Shauna, Clarke, William, Marzinke, Mark A, Fiamma, Agnès, Donnell, Deborah, Kulich, Michal, Mbwambo, Jessie K.K, Richter, Linda, Gray, Glenda, Sweat, Michael, Coates, Thomas J, Eshleman, Susan H
Format:	Artikel
Sprache:	eng
Schlagworte:	Africa Africa, Southern Allergy and Immunology Diagnosis Enzyme immunoassay Fourth-generation HIV HIV - immunology HIV Antibodies - immunology HIV Antigens - immunology HIV Core Protein p24 - immunology HIV Infections - diagnosis HIV Infections - immunology HIV Infections - virology HIV-1 - immunology HIV-2 - immunology Human immunodeficiency virus Human immunodeficiency virus 1 Human immunodeficiency virus 2 Humans Immunoenzyme Techniques - methods Immunoenzyme Techniques - standards Infectious Disease Reagent Kits, Diagnostic - standards Reproducibility of Results Sensitivity and Specificity
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Zusammenfassung:	Highlights • The sensitivity of the Bio-Rad Combo assay was 100% (95% confidence interval [CI]: 98.8–100%) in this African cohort. • The specificity of the Bio-Rad Combo assay was 96.7% (95% CI: 94.0–98.4%)) in this African cohort. • The Bio-Rad Combo assay identified acute/early HIV infections.
ISSN:	1386-6532 1873-5967
DOI:	10.1016/j.jcv.2014.11.023